1. From the Departments of Clinical Pharmacology and Therapeutics (M.K., M.M., M.M., M.O., T.A., Y.I.), the Nephrology, Hypertension, and Endocrinology (S.I.), Public Health (A.H., T.O., I.T., S.H.), Environmental Health Science (H.S.), Tohoku University Graduate School of Medicine and Pharmaceutical Science, Sendai; and Ohasama Hospital (K.N.), Iwate, Japan.