Poor Collateral Circulation Assessed by Multiphase Computed Tomographic Angiography Predicts Malignant Middle Cerebral Artery Evolution After Reperfusion Therapies

Author:

Flores Alan1,Rubiera Marta1,Ribó Marc1,Pagola Jorge1,Rodriguez-Luna David1,Muchada Marian1,Boned Sandra1,Seró Laia1,Sanjuan Estela1,Meler Pilar1,Carcámo Daniel1,Santamarina Estevo1,Tomassello Alejandro1,Lemus Miguel1,Coscojuela Pilar1,Molina Carlos A.1

Affiliation:

1. From the Neurology Department, Hospital de Clínicas, U.N.A. San Lorenzo, Paraguay (A.F.); Stroke Unit (M. Rubiera, M. Ribó, J.P., D.R.-L., M.M., S.B., L.S., E.S., P.M., E.S., C.A.M.) and Neuroradiology Department (M.R., M.R., J.P., D.R.-L., M.M., S.B., L.S., E.S., P.M., E.S., A.T., M.L., P.C., C.A.M.), Vall D’ Hebron Hospital, Barcelona, Spain; and Neurology Department, Clínica Alemana, Santiago, Chile (D.C.).

Abstract

Background and Purpose— Collateral circulation (CC) has been associated with recanalization, infarct volume, and clinical outcome in patients undergoing acute reperfusion therapies. However, its relationship with the development to malignant middle cerebral artery infarction (mMCAi) has not been evaluated. Our aim was to determine the impact of CC using multiphase computed tomographic angiography (during the acute stroke phase in the prediction of mMCAi. Methods— Patients with consecutive acute stroke with <4.5 hours who were evaluated for reperfusion therapies and presented with an M1-MCA or terminal internal carotid artery occlusion by CTA were included. CC was evaluated on 6 grades by multiphase CTA according to the University of Calgary CC Scale; CC status was defined as poor (grades, 0–3) or good (grades, 4–5). The mMCAi was defined according to clinical and radiological criteria. Recanalization was assessed with transcranial Doppler at 24 hours and final Thrombolysis in Brain Ischemia score ≥2b in patients undergoing endovascular reperfusion treatment. Results— Eighty-two patients were included. Mean age was 65.1±13.83 years, median baseline National Institutes of Health Stroke Scale score was 18 (interquartile range, 13–20), and 67.9% M1 and 32.1% terminal internal carotid artery occlusions. Fifty-three patients received endovascular reperfusion treatment. Fifteen patients developed mMCAi. In the univariate analysis, patients with mMCAi had lower CC scores (2.29 versus 3.71; P =0.001). Endovascular reperfusion treatment was associated with lower rate of mMCAi development than only intravenous reperfusion treatment (9.4% versus 29.6%; P =0.028). Patients with poor CC had higher risk of developing mMCAi (13% versus 2%; P =0.001). On the multivariate analysis adjusted by age, vessel occlusion, baseline National Institutes of Health Stroke Scale, and recanalization, the presence of poor CC by multiphase CTA was the only independent predictor of mMCAi ( P =0.048; odds ratio, 9.72; 95% confidence interval, 1.387–92.53). Conclusions— CC assessment by multiphase CTA independently predicts malignant MCA infarction progression. In patients with persistent occlusion after reperfusion therapies, the presence of poor CC may improve the early mMCAi detection and management.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology

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