Cumulative Concussion and Odds of Stroke in Former National Football League Players

Author:

Brett Benjamin L.1ORCID,Kerr Zachary Y.2ORCID,Aggarwal Neelum T.3,Chandran Avinash24ORCID,Mannix Rebekah5,Walton Samuel2ORCID,DeFreese J.D.2ORCID,Echemendia Ruben J.6ORCID,Guskiewicz Kevin M.2ORCID,McCrea Michael A.1,Meehan William P.5

Affiliation:

1. Department of Neurosurgery, Medical College of Wisconsin, Wauwatosa (B.L.B., M.A.M.).

2. Department of Exercise and Sport Science, University of North Carolina at Chapel Hill (Z.Y.K., A.C., S.W., J.D.D., K.M.G.).

3. Rush Alzheimer’s Disease Center, Chicago, IL (N.T.A.).

4. Datalys Center for Sports Injury Research and Prevention, Indianapolis, IN (A.C.).

5. Boston Children’s Hospital, MA (R.M., W.P.M.).

6. Psychological and Neurobehavioral Associates, Inc, State College, PA (R.J.E.).

Abstract

Background and Purpose: Postmortem and experimental studies indicate a potential association between repeated concussions and stroke risk in older contact sport athletes. We examined the relationship between concussion and stroke history in former National Football League players aged ≥50 years. Methods: Former professional football players aged ≥50 years who played ≥1 year in the National Football League were enrolled in the cross-sectional study. Indirect standardization was used to calculate overall and decade-specific standardized prevalence ratios. Logistic regression using Firth’s bias reduction method examined the association between lifetime concussion history 0 (n=119; 12.2%), 1 to 2 (n=152; 15.5%), 3 to 5 (n=242; 24.7%), 6 to 9 (201; 20.5%), and 10+(n=265; 27.1%) and stroke. Adjusted odds ratios for stroke were calculated for concussion history groups, age, and coronary artery disease and/or myocardial infarction. Results: The 979 participants who met inclusion criteria had a mean age of 65.0±9.0 years (range, 50–99). The prevalence of stroke was 3.4% (n=33), significantly lower than expected based on rates of stroke in US men aged 50 and over (standardized prevalence ratio=0.56, Z= −4.56, P <0.001). Greater odds of stroke history were associated with concussion history (10+ versus 0, adjusted odds ratio [95% CI]=5.51 [1.61–28.95]), cardiovascular disease (adjusted odds ratio [95% CI]=2.24 [1.01–4.77]), and age (1-year-increase adjusted odds ratio [95% CI]=1.07 [1.02–1.11]). Conclusions: The prevalence of stroke among former National Football League players aged ≥50 years was lower than the general population, with significantly increased risk among those with 10 or more prior concussions. Findings add to the evidence suggesting that traumatic brain injuries are associated with increased risk of stroke. Clinically, management of cardio- and cerebrovascular health may be pertinent to those with a history of multiple prior concussions.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Neurology (clinical)

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