1. From the Department of Physiology (K.L., J.C.K., B.J.C.) and Department of Obstetrics and Gynaecology, (J.C.K., B.J.C.), University of Toronto, Toronto, Ontario, Canada; and Department of Cellular and Molecular Medicine (S.J.B., S.A.B.), Department of Pathology and Laboratory Medicine (D.G.), and Interdisciplinary School of Health Sciences (S.A.B.), University of Ottawa, Ottawa, Ontario, Canada.