1. From the Departments of Medicine (Cardiology) (T.A., C.B., C.P., M.K., S.R., S.B., N.F., J.M.I), Surgery (Cardiovascular) (J.F.S.), and Biomedical Research (T.A., C.B., C.P., M.K., S.R., S.B., N.F., J.M.I.), St Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, Mass; and the Department of Cardiovascular Research (S.B., N.F.), Genentech, Inc, South San Francisco, Calif.