Coronary Flow Reserve in Young Men With Familial Combined Hyperlipidemia

Author:

Pitkänen Olli-Pekka1,Nuutila Pirjo1,Raitakari Olli T.1,Porkka Kimmo1,Iida Hidehiro1,Nuotio Ilpo1,Rönnemaa Tapani1,Viikari Jorma1,Taskinen Marja-Riitta1,Ehnholm Christian1,Knuuti Juhani1

Affiliation:

1. From the Departments of Medicine (O.-P.P., P.N., I.N., T.R., J.V.) and Clinical Physiology (O.T.R.) and the Turku PET Centre (J.K.), Turku University, Turku, Finland; National Public Health Institute, Helsinki, Finland (K.P., C.E.); Department of Medicine (M.-R.T.), Helsinki University, Helsinki, Finland; and Research Institute for Brain and Blood Vessels-Akita (H.I.), Akita, Japan.

Abstract

Background —Familial combined hyperlipidemia (FCHL) is a common hereditary disorder of lipoprotein metabolism estimated to cause 10% to 20% of premature coronary heart disease. We investigated whether functional abnormalities exist in coronary reactivity in asymptomatic patients with FCHL. Methods and Results —We studied 21 male FCHL patients (age, 34.8±5.4 years) and a matched group of 21 healthy control subjects. Myocardial blood flow (MBF) was measured at baseline and during dipyridamole-induced hyperemia with PET and 15 O-labeled water. The baseline MBF was similar in patients and control subjects (0.79±0.19 versus 0.88±0.20 mL · g −1 · min −1 , P =NS). An increase in MBF was seen in both groups after dipyridamole infusion, but MBF at maximal vasodilation was lower in FCHL patients (3.54±1.59 versus 4.54±1.17 mL · g −1 · min −1 , P =0.025). The difference in coronary flow reserve (CFR) was not statistically significant (4.7±2.2 versus 5.3±1.6, P =NS, patients versus control subjects). Considerable variability in CFR values was detected within the FCHL group. Patients with phenotype IIB (n=8) had lower flow during hyperemia (2.5±1.2 versus 4.2±1.5 mL · g −1 · min −1 , P <0.05) and lower CFR (3.4±2.1 versus 5.4±2.0, P <0.05) compared with phenotype IIA (n=13). Conclusions —Abnormalities in coronary flow regulation exist in young asymptomatic FCHL patients expressing phenotype IIB (characterized by abnormalities in both serum cholesterol and triglyceride concentrations). This is in line with previous observations suggesting that the metabolic abnormalities related to the pathophysiology of FCHL are associated with the phenotype IIB.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3