1. From the Departments of Physiology and Medicine (H.S., B.G.-K., D.Z., M.G.T., G.Y.O., P.H.B.), Division of Cardiology (M.G.T., G.Y.O., P.H.B.), University Health Network, and Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research (P.H.B.), University of Toronto, Canada; and Institute for Molecular Biotechnology (J.M.P.), Austrian Academy of Science, Vienna.