1. From the Harvard Clinical Research Institute (D.E.C., A.G.C., D.S.B., M.S.C., S.M., J.M., A.B., D.J.C., R.E.K., K.K.L.H.), Beth Israel Deaconess Medical Center (D.E.C., D.J.C., K.K.L.H.), Brigham and Women’s Hospital (D.S.B., R.E.K.), Boston, Mass; and Lahey Clinic (M.S.C.), Burlington, Mass.