1. From the Departments of Pharmacology (S.S.C., H.W., T.Y., T.P.Z., D.M.R.) and Medicine (D.M.S., T.P.Z., D.M.R.), Physiology and Biophysics (K.S.W.), and Cell & Developmental Biology (T.P.Z.) and Center for Human Genetics Research (J.S.B.), Vanderbilt University School of Medicine, Nashville, Tenn; and Cardiovascular Research Center (C.G.B.), Massachusetts General Hospital, Boston.