Role of the Ubiquitin Proteasome System in the Heart-Reference-Cited by-同舟云学术

Role of the Ubiquitin Proteasome System in the Heart

Published:2013-03-29 Issue:7 Volume:112 Page:1046-1058
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circ Res

Author:

Pagan Julia¹,Seto Tiffany¹,Pagano Michele¹,Cittadini Antonio¹

Affiliation:

1. From the Department of Translational Medical Sciences, University “Federico II,” Naples, Italy (A.C.). and the Department of Pathology, NYU Cancer Institute, New York University School of Medicine, and The Howard Hughes Medical Institute, New York, NY (J.P., T.S., M.P.).

Abstract

Proper protein turnover is required for cardiac homeostasis and, accordingly, impaired proteasomal function appears to contribute to heart disease. Specific proteasomal degradation mechanisms underlying cardiovascular biology and disease have been identified, and such cellular pathways have been proposed to be targets of clinical relevance. This review summarizes the latest literature regarding the specific E3 ligases involved in heart biology, and the general ways that the proteasome regulates protein quality control in heart disease. The potential for therapeutic intervention in Ubiquitin Proteasome System function in heart disease is discussed.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.112.300521

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