Antiarrhythmic and Anti-Inflammatory Effects of Sacubitril/Valsartan on Post-Myocardial Infarction Scar-Reference-Cited by-同舟云学术

Antiarrhythmic and Anti-Inflammatory Effects of Sacubitril/Valsartan on Post-Myocardial Infarction Scar

Published:2024-05 Issue:5 Volume:17 Page:
ISSN:1941-3149
Container-title:Circulation: Arrhythmia and Electrophysiology
language:en
Short-container-title:Circ: Arrhythmia and Electrophysiology

Author:

Martínez-Falguera Daina¹²^ORCID,Aranyó Júlia³⁴^ORCID,Teis Albert³^ORCID,Ferrer-Curriu Gemma¹,Monguió-Tortajada Marta¹⁵^ORCID,Fadeuilhe Edgar³^ORCID,Rodríguez-Leor Oriol³⁶^ORCID,Díaz-Güemes Idoia¹,Roura Santiago¹³⁶⁷,Villuendas Roger³⁶^ORCID,Sarrias Axel³^ORCID,Bazan Victor³^ORCID,Delgado Victoria³^ORCID,Bayes-Genis Antoni¹³⁴⁶^ORCID,Bisbal Felipe³⁶^ORCID,Gálvez-Montón Carolina¹³⁶^ORCID

Affiliation:

1. ICREC Research Program, Germans Trias i Pujol Research Institute, Barcelona, Spain (D.M.-F., G.F.-C., M.M.-T., I.D.-G., S.R., A.B.-G., C.G.-M.).

2. Faculty of Medicine, University of Barcelona, Spain (D.M.-F.).

3. Heart Institute (iCOR), Germans Trias i Pujol University Hospital, Barcelona, Spain (J.A., A.T., E.F., O.R.-L., S.R., R.V., A.S., V.B., V.D., A.B.-G., F.B., C.G.-M.).

4. Department of Medicine, Autonomous University of Barcelona, Spain (J.A., A.B.-G.).

5. Department of Immunobiology, University of Lausanne, Epalinges, Vaud, Switzerland (M.M.-T.).

6. CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain (O.R.-L., S.R., R.V., A.B-G., F.B., C.G.-M.).

7. Faculty of Medicine, University of Vic-Central University of Catalonia, Barcelona, Spain (S.R.).

Abstract

BACKGROUND: Sacubitril/valsartan (Sac/Val) is superior to angiotensin-converting enzyme inhibitors in reducing the risk of heart failure hospitalization and cardiovascular death, but its mechanistic data on myocardial scar after myocardial infarction (MI) are lacking. The objective of this work was to assess the effects of Sac/Val on inflammation, fibrosis, electrophysiological properties, and ventricular tachycardia inducibility in post-MI scar remodeling in swine. METHODS: After MI, 22 pigs were randomized to receive β-blocker (BB; control, n=8) or BB+Sac/Val (Sac/Val, n=9). The systemic immune response was monitored. Cardiac magnetic resonance data were acquired at 2-day and 29-day post MI to assess ventricular remodeling. Programmed electrical stimulation and high-density mapping were performed at 30-day post MI to assess ventricular tachycardia inducibility. Myocardial samples were collected for histological analysis. RESULTS: Compared with BB, BB+Sac/Val reduced acute circulating leukocytes ( P =0.009) and interleukin-12 levels ( P =0.024) at 2-day post MI, decreased C-C chemokine receptor type 2 expression in monocytes ( P =0.047) at 15-day post MI, and reduced scar mass ( P =0.046) and border zone mass ( P =0.043). It also lowered the number and mass of border zone corridors ( P =0.009 and P =0.026, respectively), scar collagen I content ( P =0.049), and collagen I/III ratio ( P =0.040). Sac/Val reduced ventricular tachycardia inducibility ( P =0.034) and the number of deceleration zones ( P =0.016). CONCLUSIONS: After MI, compared with BB, BB+Sac/Val was associated with reduced acute systemic inflammatory markers, reduced total scar and border zone mass on late gadolinium-enhanced magnetic resonance imaging, and lower ventricular tachycardia inducibility.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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