Expansive Arterial Remodeling: Location, Location, Location

Author:

Pasterkamp Gerard1,Galis Zorina S.1,de Kleijn Dominique P.V.1

Affiliation:

1. From the Heart Lung Institute (G.P., D.P.V.d.K.), Laboratory of Experimental Cardiology, Utrecht University Hospital, Utrecht, The Netherlands; Department of Medicine (Z.S.G.), Division of Cardiology, Emory University and Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, Ga.

Abstract

The artery is a dynamic organ capable of changing its geometry in response to atherosclerotic plaque formation. Expansion of the vessel diameter retards luminal narrowing and is considered a compensatory response. However, the expansive remodeling response is a “wolf in sheep’s clothes,” because expansion is associated with the presence of inflammatory cells, proteolysis, and a thrombotic plaque phenotype. The prevalence and clinical presentation of expansively remodeled lesions may differ among vascular beds. However, it is evident that all types of atherosclerotic arterial expansive lesions share the presence of inflammatory cells and subsequent protease activities. The potential role of inflammation and protease activity in the development of the different remodeling modes is discussed.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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