1. From the Departments of Clinical Pharmacology and Therapeutics (Y.A., M.K., A.H., T.O., H.M., Y.S., K.T., Y.I.), Planning for Drug Development and Clinical Evaluation (T.O., K.A., J.H.), Environmental health Sciences (H.S.), and Physical Medicine and Rehabilitation (T.K., S.I.), Tohoku University Graduate School of Pharmaceutical Sciences and Medicine; Tohoku University 21st Century COE Program “Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation” (T...