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The Pathology of Hypertensive Pulmonary Vascular Disease

Published:1958-10 Issue:4 Volume:18 Page:533-547
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

HEATH DONALD¹,EDWARDS JESSE E.¹

Affiliation:

1. From the Mayo Clinic and the Mayo Foundation, Rochester, Minn. The Mayo Foundation is a part of the Graduate School of the University of Minnesota.

Abstract

Progressive histologic changes occur in the pulmonary arteries and arterioles, as a complication of chronically elevated pulmonary arterial blood pressure, in patients with congenital septal defects of the heart. This progression is so stereotyped as to allow a division of the structural effects into 6 grades. The histologic features of each grade are described in detail in this communication. These results afford a basis for comparing the magnitude of these changes to the clinical findings.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.18.4.533

Reference11 articles.

1. EATH 1). HELJMH)LZ 11. F. JR. BURC1HELL H. B. I)LTSHA NE J. W. AND EDWARDS J. K.: Graded pulmonary vascular changes and hemodynamic findings in cases of atrial and ventricular septal defect and patent ductus arteriosus. Unpublished data.

2. . - - - KIRKLIN J. W. AND EDWARDS. .J. F.: Relation between structural changes in the small pulmonary arteries and the reversibility of pulmonary hypertension following closure of ventricular and atrial septal defects. Unpublished data.

3. . - - - KIRKLIN J. W. AND EDWARDS. .J. F. : The relation of age and blood pressume to atheroma in the pulmonary arteries and thoracic aorta in congenital heart disease. Unpublished data.

4. . - - - KIRKLIN J. W. AND EDWARDS. .J. F. : The structure of the pulmonary trunk at different ages and in cases of pulmonary hypertension and pulmonary stenosis. J. iPath. & Bact. In press.

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