CLA-1/SR-BI Is Expressed in Atherosclerotic Lesion Macrophages and Regulated by Activators of Peroxisome Proliferator-Activated Receptors-Reference-Cited by-同舟云学术

CLA-1/SR-BI Is Expressed in Atherosclerotic Lesion Macrophages and Regulated by Activators of Peroxisome Proliferator-Activated Receptors

Published:2000-05-23 Issue:20 Volume:101 Page:2411-2417
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

Chinetti Giulia¹,Gbaguidi Franck G.¹,Griglio Sabine¹,Mallat Ziad¹,Antonucci Micheline¹,Poulain Philippe¹,Chapman John¹,Fruchart Jean-Charles¹,Tedgui Alain¹,Najib-Fruchart Jamila¹,Staels Bart¹

Affiliation:

1. From the U.325 INSERM, Département d’Athérosclerose, Institut Pasteur de Lille, and the Faculté de Pharmacie, Université de Lille II (G.C., F.G.G., P.P., J.-C.F., J.N.-F., B.S.), and U.321 INSERM, Hôpital de la Pitié (S.G., M.A., J.C.), and U.141 INSERM, Hôpital Lariboisière (Z.M., A.T.), Paris, France. The first 2 authors contributed equally to this work.

Abstract

Background —The scavenger receptors are cell-surface receptors for native and modified lipoproteins that play a critical role in the accumulation of lipids by macrophages. CLA-1/SR-BI binds HDL with high affinity and is involved in the cholesterol reverse-transport pathway. Peroxisome proliferator–activated receptors (PPARs) are transcription factors regulating the expression of genes implicated in lipid metabolism, cellular differentiation, and inflammation. Here, we investigated the expression of CLA-1/SR-BI in macrophages and its regulation by PPARs. Methods and Results —CLA-1 is undetectable in human monocytes and is induced upon differentiation into macrophages. Immunohistological analysis on human atherosclerotic lesions showed high expression of CLA-1 in macrophages of the lipid core colocalizing with PPARα and PPARγ staining. Activation of PPARα and PPARγ resulted in the induction of CLA-1 protein expression in monocytes and in differentiated macrophages. Finally, SR-BI expression is increased in atherosclerotic lesions of apoE-null mice treated with either PPARγ or PPARα ligands. Conclusions —Our data demonstrate that CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and induced by PPAR activation, identifying a potential role for PPARs in cholesterol homeostasis in atherosclerotic lesion macrophages.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.101.20.2411

Reference45 articles.

1. LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

2. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

3. An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors.

4. Molecular flypaper and atherosclerosis: structure of the macrophage scavenger receptor

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