Myocardial Infarction in Rats Fed Diets Containing High Fat, Cholesterol, Thiouracil, and Sodium Cholate

Author:

THOMAS WILBUR A.1,HARTROFT W. STANLEY1

Affiliation:

1. From the Department of Pathology, Washington University School of Medicine, St. Louis, Mo.

Abstract

Investigators have produced arteriosclerosis in experimental animals by dietary means for almost half a century. In contrast to the situation in man, however, all previous reports indicate that complicating thrombosis and infarction have been extremely rare in experimental animals. The current report presents dietary regimens by means of which the authors have produced significant numbers of myocardial and renal infarcts in rats (6 of 10 in one group and 4 of 10 in each of 2 others). It is notable that thrombosis occurred before the appearance of severe structural changes in the arterial walls, although abundant fat could often be demonstrated histochemically.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference13 articles.

1. FILLIos L. C. ANDRUS S. B. MANN G. V. AND STARE F. J.: Experimental production of gross atheroselerosis in the rat. J. Exper.

2. WISSLER , R. W. , EILERT , M. L. , SCHROEDER , Med. 104 : 539 , 1956 .

3. Calcified atheromnatosis in the rat;WILGRAM G. F.;Fed. Proc.,1957

4. PATHOLOGICAL LESIONS RELATED TO DISTURBANCES OF FAT AND CHOLESTEROL METABOLISM IN MAN

5. Thromboembolism, pulmonary arteriosclerosis and fatty meals;THOMAS W. A.;A. M. A. Arch. Path.,1956

Cited by 163 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3