Direct Renin Inhibition With Aliskiren Protects Against Myocardial Ischemia/Reperfusion Injury by Activating Nitric Oxide Synthase Signaling in Spontaneously Hypertensive Rats

Author:

Zhang Wen1,Han Yi2,Meng Guoliang1,Bai Wenli1,Xie Liping1,Lu Hui1,Shao Yongfeng3,Wei Lei3,Pan Shiyang4,Zhou Suming2,Chen Qi1,Ferro Albert5,Ji Yong1

Affiliation:

1. Key Laboratory of Cardiovascular Disease and Molecular Intervention, State Key Laboratory of Reproductive Medicine, Atherosclerosis Research Centre, Nanjing Medical University, Nanjing, China

2. Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

3. Department of Cardiothoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

4. Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

5. Department of Clinical Pharmacology, Cardiovascular Division, School of Medicine, King's College London, London, UK

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Reference33 articles.

1. Oxidative stress and cardiovascular disease;Griendling KK;Circulation,1997

2. The Role of Nitric Oxide in Myocardial Repair and Remodeling

3. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia‐reperfusion;Siegfried MR;J Pharmacol Exp Ther,1992

4. Aliskiren: the first renin inhibitor for clinical treatment

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