Abstract
Calcareous corneal degeneration is a rare disease characterized by calcium phosphate deposition into the deep corneal layers. Corneal calcification has a multifactorial origin and is associated with various systemic and ocular conditions. Several treatment options showed promising results in the management of this disorder. Herein, two cases of calcareous degeneration occurring postoperatively in patients undergoing surgery for retinal detachment (case #1) and glaucoma (case #2) were reported. Despite normal serum calcium and phosphate levels, the patients developed corneal calcification after using topical steroid-phosphate drops. Treatment involved discontinuation of topical therapy and substitution with unpreserved phosphate-free lubricants. While case #1 resolved with conservative measures, which allowed a satisfactory visual recovery, case #2 required superficial keratectomy due to refractory calcification. Therefore, a correct diagnosis, careful lesion analysis, and tailored management are advisable in corneal calcification, with conservative measures being effective in most cases. At the same time, surgical intervention is necessary in refractory or advanced diseases.