Recent scientific research has shown the use of chlorin, phthalocyanines, and porphyrinsderivatives as photosensitizers in photodynamic therapy in the treatment of various pathologies, includingsome of the major skin diseases. Thus, the main goal of this critical review is to catalog the papers that usedthese photosensitizers in the treatment of acne vulgaris, psoriasis, papillomavirus infections, cutaneousleishmaniasis, and skin rejuvenation, and to explore the photodynamic therapy mechanisms against theseconditions alongside their clinical benefits.