CRP/Albumin Değerinin Koronavirüs-19 Hastalarının Hastanede Yatış Süresi ve Hastanede Kalış Süresi Üzerindeki Klinik Önemi: Prospektif Çalışma Çalışma

Abstract

Objective: To investigate the diagnostic and prognostic significance of the C-reactive protein-to-albumin ratio (CAR) in coronavirus disease 2019 (COVID- 19) patients admitted for the first time to a hospital emergency department (ED). Materials and methods: The study we report herein was a single-center, prospective observational study. A total of 745 participants (385 patients, 360 individuals) were included in the study. The CAR was calculated by dividing the C-reactive protein (CRP; mg/L) value by the albumin value (gr). The data were analyzed using MedCalc Statistical Software v12.7.0.0 (Ostend, Belgium) and Student’s t-test, chi square test, and Pearson’s correlation coefficient. A p-value of <0.05was considered statistically significant. Results: A total of 355 patients were hospitalized, and 30 of them were followed as outpatients. The mean CAR values of the hospitalized patients and the outpatients were 0.34±0.89 and 0.39±0.72 respectively (95% confidence interval [CI]: -0.31 to 0.40; p=0.796). A 309 patients were hospitalized in wards and 46, in intensive care units; their mean CAR values were 0.33±0.92 and 0.44±0.74, respectively (95% CI: -0.17 to 0.39; p=0.449). As the CAR value increased, the length of hospital stay also increased (p<0.0001). At the best cut-off point for COVID-19 diagnosis, CAR was shown to have 82.66% specificity, 69.72% sensitivity, 4.02 positive likelihood, and 0.37 negative likelihood. Conclusion: The length of stay in the hospital of the COVID-19 patients in the study was closely related to their CAR values obtained at the time of their first ED admission.s closely related to their CAR values obtained at the time of their first ED admission.