Genkwanin Regulates Tumor Necrosis Factor-á-Induced Hacat Cells Proliferation and Inflammatory Cytokines in Psoriasis by Regulating Nuclear Factor-Kappa B Signaling Pathway

Abstract

Genkwanin is an O-methylated flavone, a type of flavonoid, isolated from the spice plant Daphne genkwa. This is a highly safe anti-inflammatory, antioxidant, and anti-tumor agent. Herein, we have examined the effect of genkwanin on psoriasis in which human keratinocytes are susceptible to activation by cytokines secreted by immune cells. In psoriasis, nuclear factor-kappa B signaling pathway and inflammation is excessively activated. However, the regulatory role of genkwanin in psoriasis has not yet been elucidated. The study is designed to evaluate the effect of genkwanin on human immortal keratinocyte HaCaT.