Heart failure, a frequent complication of hypertension, is the primary risk factor of myocardial infarction. Therefore, it is important to find newer and effective treatments for hypertension comorbid with heart failure. A combination of amlodipine besylate and ligusticum, both known antihypertensives, was evaluated in hypertension complicated with heart failure with the goal of providing improved treatment. To this end, 172 hypertensive patients with heart failure received a conventional therapy or amlodipine besylate combined with ligusticum. Following treatment, all subjects were evaluated for clinical efficacy, safety, blood pressure, cardiac function, vascular endothelial function, and heart failure markers. The two groups were followed up for 1 year, and their prognosis and life quality were investigated. The treatment resulted in improvement in all markers, a higher total effectiveness rate with similar incidence of adverse reactions. Therefore, amlodipine besylate combined with ligusticum may be an effective and safe treatment for hypertension complicated with heart failure.