The microtubule- and PP1-binding activities of Drosophila melanogaster Spc105 control the kinetics of SAC satisfaction-Reference-Cited by-同舟云学术

The microtubule- and PP1-binding activities of Drosophila melanogaster Spc105 control the kinetics of SAC satisfaction

Published:2022-01-01 Issue:1 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Audett Margaux R.¹²,Johnson Erin L.¹,McGory Jessica M.¹²,Barcelos Dylan M.¹,Szalai Evelin Oroszne³,Przewloka Marcin R.³,Maresca Thomas J.¹²

Affiliation:

1. Biology Department, University of Massachusetts, Amherst, Amherst MA 01003

2. Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, Amherst MA 01003

3. Institute for Life Sciences, School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK

Abstract

The large, disordered kinetochore protein KNL1/Spc105 is a key regulator of the SAC. Bub3 binding to divergent repeats in fly Spc105 is promoted by Aurora B kinase while Spc105’s N-terminus has MT- and PP1-binding activities that contribute to SAC satisfaction. Optogenetic oligomerization of Spc105 triggers simultaneous binding to MTs and PP1.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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