FOXM1 nuclear transcription factor translocates into mitochondria and inhibits oxidative phosphorylation-Reference-Cited by-同舟云学术

FOXM1 nuclear transcription factor translocates into mitochondria and inhibits oxidative phosphorylation

Published:2020-06-15 Issue:13 Volume:31 Page:1411-1424
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Black Markaisa¹,Arumugam Paritha²³,Shukla Samriddhi¹,Pradhan Arun¹³,Ustiyan Vladimir¹³,Milewski David¹,Kalinichenko Vladimir V.¹⁴³,Kalin Tanya V.¹³

Affiliation:

1. Perinatal Institute and Division of Neonatology, Perinatal and Pulmonary Biology

2. Translational Pulmonary Science Center and Division of Pulmonary Biology, Cincinnati, OH 45229-3039

3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267

4. Center for Lung Regenerative Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229-3039

Abstract

It was found that the transcription factor FOXM1 translocates into mitochondria and inhibits mitochondrial respiration and membrane potential, directly binds to mitochondrial PTCD1, and inhibits the electron transport chain by stabilizing PTCD1.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference62 articles.

1. Mitochondrial transcription and its regulation in mammalian cells

2. Foxm1 transcription factor is required for macrophage migration during lung inflammation and tumor formation

3. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition

4. Endothelial Cell–Specific Deletion of Transcription Factor FoxM1 Increases Urethane-Induced Lung Carcinogenesis

5. FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts

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