Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner-Reference-Cited by-同舟云学术

Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner

Published:2020-06-01 Issue:12 Volume:31 Page:1259-1272
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Latario Casey J.¹,Schoenfeld Lori W.¹,Howarth Charles L.²,Pickrell Laura E.¹,Begum Fatema¹,Fischer Dawn A.³,Grbovic-Huezo Olivera⁴,Leach Steven D.²,Sanchez Yolanda²,Smith Kerrington D.³,Higgs Henry N.¹

Affiliation:

1. Department of Biochemistry and Cell Biology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755

2. Department of Molecular and Systems Biology, and Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755

3. Department of Surgery, Division of Surgical Oncology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756

4. David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065

Abstract

We identify tumor microtubes (TMTs) and cell-substrate protrusions (CSPs) in a pancreatic cancer line, in cell culture, tumor models, and a subset of primary human tumors. TMTs and CSPs emanate from the lateral plasma membrane and contain actin filaments, microtubules, and cytokeratin. Arp2/3 complex drives two distinct TMT assembly mechanisms.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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