p52Shc regulates the sustainability of ERK activation in a RAF-independent manner-Reference-Cited by-同舟云学术

p52Shc regulates the sustainability of ERK activation in a RAF-independent manner

Published:2021-09-01 Issue:19 Volume:32 Page:1838-1848
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Yoshizawa Ryo¹²,Umeki Nobuhisa¹,Yamamoto Akihiro¹,Okada Mariko³⁴,Murata Masayuki²,Sako Yasushi¹

Affiliation:

1. Cellular Informatics Lab, RIKEN, Wako, Saitama 351-0198, Japan

2. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro, Tokyo 153-8902, Japan

3. Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan

4. Center for Drug Design and Research, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki 567-0085, Japan

Abstract

SHC and GRB2 transduce ERBB signals to the cytoplasm. Unexpectedly, these proteins show distinct translocation dynamics. Sustained SHC dynamics induces sustained ERK activation via a pathway from PI3K to MEK.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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