Affiliation:
1. Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755-3844
Abstract
Vacuole membranes contain several lipid species. Membrane fusion occurs very poorly with just phosphatidylcholine. We now report that PI, PI3P, and Erg first activate HOPS to catalyze assembly of trans-SNARE complexes, and then PE, PS, PA, and DAG facilitate membrane bilayer rearrangements for complete fusion.
Publisher
American Society for Cell Biology (ASCB)
Subject
Cell Biology,Molecular Biology
Cited by
13 articles.
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