Phosphatidylinositol and phosphatidylinositol-3-phosphate activate HOPS to catalyze SNARE assembly, allowing small headgroup lipids to support the terminal steps of membrane fusion

Author:

Torng Thomas1,Wickner William1

Affiliation:

1. Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755-3844

Abstract

Vacuole membranes contain several lipid species. Membrane fusion occurs very poorly with just phosphatidylcholine. We now report that PI, PI3P, and Erg first activate HOPS to catalyze assembly of trans-SNARE complexes, and then PE, PS, PA, and DAG facilitate membrane bilayer rearrangements for complete fusion.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Sec18 binds the tethering/SM complex HOPS to engage the Qc-SNARE for membrane fusion;Molecular Biology of the Cell;2024-05-01

2. MARCKS Effector Domain, a reversible lipid ligand, illuminates late stages of membrane fusion;Molecular Biology of the Cell;2023-11-01

3. Efficient fusion requires a membrane anchor on the vacuolar Qa-SNARE;Molecular Biology of the Cell;2023-08-01

4. The machinery of vesicle fusion;Current Opinion in Cell Biology;2023-08

5. Role of GARP Vesicle Tethering Complex in Golgi Physiology;International Journal of Molecular Sciences;2023-03-23

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