The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration-Reference-Cited by-同舟云学术

The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration

Published:2023-03-01 Issue:3 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Wong Darren Chen Pei¹,Pan Catherine Qiurong¹,Er Shi Yin²,Thivakar T.¹,Rachel Tan Zi Yi¹,Seah Sock Hong¹,Chua Pei Jou³,Jiang Tingting²,Chew Ti Weng¹,Chaudhuri Parthiv Kant¹,Mukherjee Somsubhro¹,Salim Agus⁴,Aye Thike Aye⁵,Koh Cheng Gee⁶,Lim Chwee Teck¹⁷,Tan Puay Hoon⁵,Bay Boon Huat³,Ridley Anne J.⁸,Low Boon Chuan¹²⁹

Affiliation:

1. Mechanobiology Institute, National University of Singapore, Singapore 117411

2. Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, Singapore 117558

3. Department of Anatomy, Yong Loo Lin School of Medicine, National University Health System, Singapore 117594

4. Melbourne School of Population and Global Health and School of Mathematics and Statistics, The University of Melbourne, Melbourne, Victoria 3052, Australia

5. Department of Pathology, Singapore General Hospital, Singapore 169856

6. Division of Molecular Genetics & Cell Biology, School of Biological Sciences, Nanyang Technological University, Singapore 637551

7. Department of Biomedical Engineering, National University of Singapore, Singapore 117583

8. School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, United Kingdom

9. NUS College, National University of Singapore, Singapore 138593

Abstract

How the activities of Rho and Rac are coordinated through their GEF and GAP remains unclear. The prometastatic RhoGAP, BPGAP1, recruits the RacGEF Vav1 to activate Rac1 while it down-regulates the local RhoA activity that in turns influences Rac1 activation by Vav1. BPGAP1 acts as a scaffold to synchronize Rho and Rac signaling in cell motility.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference57 articles.

1. Activation of Vav/Rho GTPase Signaling by CXCL12 Controls Membrane-Type Matrix Metalloproteinase–Dependent Melanoma Cell Invasion

2. Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation

3. Vav family exchange factors: an integrated regulatory and functional view

4. A Perspective on Cancer Cell Metastasis

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Interaction between Solo and PDZ-RhoGEF is involved in actin cytoskeletal remodeling and response to substrate stiffness;2023-11-08

2. A Rab-bit hole: Rab40 GTPases as new regulators of the actin cytoskeleton and cell migration;Frontiers in Cell and Developmental Biology;2023-09-06

3. Knockdown of ARHGAP30 inhibits ovarian cancer cell proliferation, migration, and invasiveness by suppressing the PI3K/AKT/mTOR signaling pathway;European Journal of Histochemistry;2023-05-11

4. ARHGAP6 inhibits bladder cancer cell viability, migration, and invasion via β-catenin signaling and enhances mitomycin C sensitivity;Human Cell;2023-01-30