Salt bridges gate α-catenin activation at intercellular junctions-Reference-Cited by-同舟云学术

Salt bridges gate α-catenin activation at intercellular junctions

Published:2018-01-15 Issue:2 Volume:29 Page:111-122
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Barrick Samantha¹,Li Jing²³⁴,Kong Xinyu³,Ray Alokananda³,Tajkhorshid Emad²³⁴,Leckband Deborah¹²³⁴⁵

Affiliation:

1. Department of Chemistry, University of Illinois, Urbana, IL 61801

2. Center for Biophysics and Quantitative Biology, University of Illinois, Urbana, IL 61801

3. Department of Biochemistry, University of Illinois, Urbana, IL 61801

4. Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, IL 61801

5. Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801

Abstract

Molecular dynamics simulations, equilibrium binding measurements, and fluorescence imaging reveal the influence of a key salt bridge in the mechanical activation of α-catenin at intercellular adhesions. Simulations reveal possible α-catenin conformational changes underlying experimental fluorescence and equilibrium binding data.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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