CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy-Reference-Cited by-同舟云学术

CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy

Published:2023-04-01 Issue:4 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Ishii Shunsuke¹,Chino Haruka²,Ode Koji L.³,Kurikawa Yoshitaka²,Ueda Hiroki R.³⁴,Matsuura Akira⁵,Mizushima Noboru²,Itakura Eisuke⁵

Affiliation:

1. Department of Biology, Graduate School of Science and Engineering, Chiba University, Chiba 263-8522, Japan

2. Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Tokyo 113-0033, Japan

3. Department of Systems Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan

4. Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Osaka 565-0871, Japan

5. Department of Biology, Graduate School of Science, Chiba University, Chiba, 263-8522, Japan

Abstract

CCPG1 interacts directly with endoplasmic reticulum (ER) luminal proteins, including aggregated protein. Cargo-interacting region in CCPG1 recognizes the ER luminal proteins. The ER luminal region of CCPG1 simultaneously recognizes multiple cargos. CCPG1 is a bispecific receptor for ER luminal cargos and the autophagic membrane.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference92 articles.

1. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

2. TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

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