Mitotic DNA damage promotes chromokinesin-mediated missegregation of polar chromosomes in cancer cells-Reference-Cited by-同舟云学术

Mitotic DNA damage promotes chromokinesin-mediated missegregation of polar chromosomes in cancer cells

Published:2023-05-01 Issue:5 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Novais-Cruz Marco¹²³,Pombinho António⁴,Sousa Mafalda⁵,Maia André F.⁴²^ORCID,Maiato Helder¹²⁶^ORCID,Ferrás Cristina¹²

Affiliation:

1. Chromosome Instability & Dynamics Group, 4200-135 Porto, Portugal

2. Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal

3. Programa Doutoral em Biologia Molecular e Celular, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313, Porto, Portugal

4. BioSciences Screening Scientific Platform, 4200-135 Porto, Portugal

5. Advanced Light Microscopy Scientific Platform, i3S—Instituto de Investigação e Inovação em Saúde, 4200-135 Porto, Portugal

6. Cell Division Group, Department of Biomedicine, Faculdade de Medicina, Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

Abstract

Extensive DNA damage during mitosis promotes chromokinesin-mediated missegregation of polar chromosomes in cancer cells. A previously overlooked mechanism by which DNA damage during mitosis contributes to chromosomal instability and micronuclei formation is unveiled.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference53 articles.

1. DNA-Damage Response during Mitosis Induces Whole-Chromosome Missegregation

2. Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces

3. Dynein prevents erroneous kinetochore-microtubule attachments in mitosis

4. Polo-like kinase 1 inhibits DNA damage response during mitosis

5. Elevated polar ejection forces stabilize kinetochore–microtubule attachments