TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS-Reference-Cited by-同舟云学术

TAURINE PREVENTS AGAINST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN-INDUCED OXIDATIVE STRESS IN THE LIVER AND KIDNEY OF RATS

Published:2023-01-27 Issue: Volume: Page:
ISSN:1015-3918
Container-title:Ankara Universitesi Eczacilik Fakultesi Dergisi
language:en
Short-container-title:Ankara Ecz. Fak. Derg.

Author:

DOĞAN Muhammed Fatih¹,ÇİFTÇİ Oisman¹,BAŞAK TÜRKMEN Neşe²,ÇETİN Aslı³,ZENGİN Münevver Nazlıcan¹,ÇİFTÇİ Bedriye⁴

Affiliation:

1. PAMUKKALE ÜNİVERSİTESİ, TIP FAKÜLTESİ

2. İNÖNÜ ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ

3. İNÖNÜ ÜNİVERSİTESİ, TIP FAKÜLTESİ

4. PAMUKKALE ÜNİVERSİTESİ

Abstract

Objective: The aim of the study was to investigate the preventive effects of Taurine against 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD)-induced organ damage in rats. The environmental toxin TCDD has a high toxicity in animal and human tissues. Taurine is an amino acid found in organ cells that has and antioxidant properties and anti-inflammatory. As a result, the potential preventive effect of taurine on oxidative stress and organ damage caused by TCDD was investigated in rat liver and kidney tissues by measuring glutathione (GSH), superoxide dismutase (SOD) activity, and thiobarbituric acid reactive substances (TBARS) levels. Material and Method: Adult male Wistar rats (250-300 g, 12-13 weeks, n = 32) were randomly allocted into four groups (n = 8/group): Control, TCDD, TAU, and TCDD+TAU. TCDD and/or taurine were administered via gavage in doses of 2 μg/kg/week and 200 mg/kg/day, respectively. Result and Discussion: The results showed that TCDD caused oxidative stress in the liver and kidney tissues of rats by decreasing the levels of GSH and SOD activity and increasing the levels of TBARS. Taurine treatment significantly reduced TBARS levels (p

Publisher

Ankara Universitesi Eczacilik Fakultesi Dergisi

Subject

Pharmaceutical Science,Pharmacology

Reference40 articles.

1. 1. Pelclová, D., Urban, P., Preiss, J., Lukáš, E., Fenclová, Z., Navrátil, T., Dubská, Z., Šenholdova, Z. (2006). Adverse health effects in humans exposed to 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD). In Reviews on Environmental Health 21(2), 119–138). [CrossRef]

2. 2. Geyer, H.J., Schheunert, I., Rapp, K., Gebefugi, I., Steinberg, C., Kettrup, A. (1993). The Relevance of Fat Content in Toxicity of Lipophilic Chemicals to Terrestrial Animals with Special Reference to Dieldrin and 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). Ecotoxicology and Environmental Safety, 26(1), 45–60. [CrossRef]

3. 3. Beytur, A., Ciftci, O., Aydin, M., Cakir, O., Timurkaan, N., Y, F. (2012). Protocatechuic acid prevents reproductive damage caused by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in male rats. Andrologia, 44, 454–461.[CrossRef]

4. 4. Roth, W.L., Ernst, S., Weber, L.W.D., Kerecsen, L., Rozman, K.K. (1994). A pharmacodynamically responsive model of 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) transfer between liver and fat at low and high doses. Toxicology and Applied Pharmacology, 127(1), 151–162. [CrossRef]

5. 5. Neubert, R., Golor, G., Helge, H.,Neubert, D. (1994). Risk assessment for possible effects 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related substances on components and functions of the immune system. In Experimental and Clinical Immunogenetics (Vol. 11, Issues 2–3, pp. 163–171). Exp Clin Immunogenet. [CrossRef]