Pathophysiological mechanisms and clinical consequences of exposure of the fetus and newborn to new psychoactive substances — “bath salts”

Author:

Loshkova E. V.1ORCID,Doroshenko I. V.2ORCID,Lyulka T. S.2ORCID,Rafikov Y. S.2ORCID,Zhelev V. A.2ORCID,Ermolenko S. P.3ORCID,Mikhalev E. V.3ORCID,Grishkevich I. R.2ORCID,Melnikov N. E.4ORCID,Solnyshko A. L.4ORCID,Bogunetsky A. A.4ORCID,Kondratieva E. I.5,Khavkin A. I.6ORCID,Odinaeva N. D.7ORCID,Makarevich E. I.2ORCID

Affiliation:

1. Siberian State Medical University; Reasearch Clinical Institute of Childhood of the Ministry of Health of the Moscow Region

2. Siberian State Medical University

3. Siberian State Medical University; Children’s City Hospital No. 1

4. Children’s City Hospital No. 1

5. Reasearch Clinical Institute of Childhood of the Ministry of Health of the Moscow Region; Bochkov Medical Genetic Research Center

6. Pirogov Russian National Research Medical University

7. Reasearch Clinical Institute of Childhood of the Ministry of Health of the Moscow Region

Abstract

The use of new psychoactive substances (NPS) is increasing every year among various social groups around the world. The use of narcotic drugs during pregnancy, according to various authors, remains at a high level from 2.8% to 7% of pregnant women. The use of new psychoactive substances during pregnancy is characterized by multi-organ damage to the fetus, like other groups of narcotic drugs, however, no organ and tissue specificity for new psychoactive substances has been described. Experimental studies have demonstrated negative pathophysiological mechanisms triggered by synthetic cathinones in the form of increased proapoptotic activity, the formation of autophagolysosomes and reactive oxygen species, and the pro-inflammatory orientation of the immune system. A clinical observation describes a predominant lesion of the nervous system (malformations of the brain, damage to the respiratory center) and the musculoskeletal system (pronounced myotonic syndrome, congenital pathological fractures of the femur), which leads to multiorgan dysfunction, an uncontrolled inflammatory response, and, as a result, to the development of severe disability in such children and growth of the cohort of palliative pediatric patients. In the presented literature review, the authors focus on the pathophysiological mechanisms of action of NPS for a better, deeper and more holistic understanding of the pathological process occurring in the body, in order to form and improve the clinical thinking of medical specialists and cite their own clinical observation as an illustration of the consequences of using new psychoactive substances during pregnancy. The authors believe that this review of the literature with a description of a clinical case is valuable in terms of practical applicability, both for clinicians in various fields and for researchers.

Publisher

The National Academy of Pediatric Science and Innovation

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3