Regulatory role of circular RNAs in oral squamous cell carcinoma
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Published:2023-08-31
Issue:8
Volume:69
Page:250-257
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ISSN:1165-158X
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Container-title:Cellular and Molecular Biology
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language:
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Short-container-title:Cell Mol Biol (Noisy-le-grand)
Author:
Attar Rukset,Noel Khalida,Romero Mirna Azalea,Sabitaliyevich Uteuliyev Yerzhan,Yulaevna Ishmuratova Margarita,Qureshi Muhammad Zahid
Abstract
OSCC is a genomically complicated disease and advancements in the modern era of molecular oncology have enabled researchers to portray near-to-complete resolution of signaling landscape. Over the last two decades, overwhelming proof-of-concept has established mechanistic regulatory role of non-coding RNAs in carcinogenesis, including OSCC. Circular RNAs demonstrate a burgeoning facet of oncology research and molecular biologists are only beginning to appreciate and recognize the significance of circRNAs in the pathogenesis of OSCC. Regulatory roles of non-coding RNAs in the re-shaping of signaling pathways offer plausible strategies for prevention/inhibition of OSCC. Circular RNAs have mechanistic roles in OSCC and "sponge effects" mediated by a wider variety of circRNAs need to be rationally targeted for effective cancer prevention. Phenomenal and cutting-edge research works in different types of animal models will further refine our knowledge for selection of most promising circRNAs as pharmacologically valuable targets.
Publisher
CMB Association