A Multispecies Cluster of VIM-1 Carbapenemase-Producing Enterobacterales Linked by a Novel, Highly Conjugative, and Broad-Host-Range IncA Plasmid Forebodes the Reemergence of VIM-1

Author:

Arcari Gabriele1,Di Lella Federica Maria2,Bibbolino Giulia3,Mengoni Fabio4,Beccaccioli Marzia5,Antonelli Guido1,Faino Luigi5,Carattoli Alessandra1ORCID

Affiliation:

1. Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

2. Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy

3. Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy

4. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy

5. Department of Environmental Biology, Sapienza University of Rome, Rome, Italy

Abstract

In this study, we investigated VIM-1-producing Escherichia coli , Klebsiella oxytoca , Klebsiella pneumoniae , Citrobacter freundii , and Enterobacter cloacae strains, isolated in 2019 during a period of active surveillance of carbapenem-resistant Enterobacterales in a large university hospital in Italy. VIM-1-producing strains colonized the gut of patients, with up to three different VIM-1-positive bacterial species isolated from a single rectal swab, but also caused bloodstream infection in one colonized patient.

Funder

Sapienza Università di Roma

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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