Inhibition of CD1 Expression in Human Dendritic Cells during Intracellular Infection with Leishmania donovani-Reference-Cited by-同舟云学术

Inhibition of CD1 Expression in Human Dendritic Cells during Intracellular Infection with Leishmania donovani

Published:2004-01 Issue:1 Volume:72 Page:589-592
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Amprey Joseph L.¹²,Späth Gerald F.³,Porcelli Steven A.²

Affiliation:

1. Weill Medical College of Cornell University

2. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York

3. Department of Medical and Molecular Parasitology, New York University School of Medicine, New York

Abstract

ABSTRACT Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.1.589-592.2004

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