Synergistic Antibacterial Activity of Clavulanic Acid and Amoxicillin Against β-Lactamase-Producing Strains of Haemophilus ducreyi

Author:

Girouard Yves C.1,Maclean Ian W.2,Ronald Allan R.21,Albritton William L.23

Affiliation:

1. Department of Medicine University of Manitoba, Winnipeg, Manitoba, Canada R3E 0Z3

2. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0Z3

3. Department of Pediatrics,3 University of Manitoba, Winnipeg, Manitoba, Canada R3E 0Z3

Abstract

The susceptibility of 47 strains of Haemophilus ducreyi to amoxicillin, clavulanic acid, and the combination of both drugs was determined by agar dilution susceptibility testing. A synergistic antibacterial activity of the combination was found for β-lactamase-producing strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference16 articles.

1. Naturally occurring /3-lactamase inhibitors with antibacterial ac- tivity;Brown A. G. B.;J. Antibiot.,1976

2. Plasmid-mediated ampicillin resistance in Haemophihlu ducreyi;Brunton J. L;Antimicrob. Agents Chemother.,1979

3. Ericson H. B. and J. C. Sherris. 1971. Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathol. Microbiol. Scand. Sect. B. Suppl. 217. NOTES 145

4. Minimal inhibitory concentration of 34 antimicrobial agents for control strains Escherichia coli ATCC 25922 and Pseudomonas aerugmosa ATCC 27583;Fass R. J.;Antimicrob. Agents Chemother.,1979

5. A comparison of the in vitro activity of rosamicin, erythromycin, clindamycin, metronidazole and ornidazole against Haemophilus ducreyi, including M-lactamase producing strains;Feltham S.;J. Antimicrob. Chemother.,1979

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