Avian Influenza Virus (H5N1): a Threat to Human Health

Author:

Peiris J. S. Malik123,de Jong Menno D.123,Guan Yi123

Affiliation:

1. Department of Microbiology, University Pathology Building, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, SAR, People's Republic of China

2. Hong Kong University—Pasteur Research Centre, Sassoon Rd., Pokfulam, Hong Kong, SAR, People's Republic of China

3. Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Ho Chi Minh City, Vietnam

Abstract

SUMMARY Pandemic influenza virus has its origins in avian influenza viruses. The highly pathogenic avian influenza virus subtype H5N1 is already panzootic in poultry, with attendant economic consequences. It continues to cross species barriers to infect humans and other mammals, often with fatal outcomes. Therefore, H5N1 virus has rightly received attention as a potential pandemic threat. However, it is noted that the pandemics of 1957 and 1968 did not arise from highly pathogenic influenza viruses, and the next pandemic may well arise from a low-pathogenicity virus. The rationale for particular concern about an H5N1 pandemic is not its inevitability but its potential severity. An H5N1 pandemic is an event of low probability but one of high human health impact and poses a predicament for public health. Here, we review the ecology and evolution of highly pathogenic avian influenza H5N1 viruses, assess the pandemic risk, and address aspects of human H5N1 disease in relation to its epidemiology, clinical presentation, pathogenesis, diagnosis, and management.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Reference270 articles.

1. Alexander, D. J. 2000. A review of avian influenza in different bird species. Vet. Microbiol.74:3-13.

2. Anonymous. 2005. Evolution of H5N1 avian influenza viruses in Asia. Emerg. Infect. Dis.11:1515-1521.

3. Apisarnthanarak, A., R. Kitphati, K. Thongphubeth, P. Patoomanunt, P. Anthanont, W. Auwanit, P. Thawatsupha, M. Chittaganpitch, S. Saeng-Aroon, S. Waicharoen, P. Apisarnthanarak, G. A. Storch, L. M. Mundy, and V. J. Fraser. 2004. Atypical avian influenza (H5N1). Emerg. Infect. Dis.10:1321-1324.

4. Banks, J., E. Speidel, and D. J. Alexander. 1998. Characterisation of an avian influenza A virus isolated from a human—is an intermediate host necessary for the emergence of pandemic influenza viruses? Arch. Virol.143:781-787.

5. Baum, L. G., and J. C. Paulson. 1990. Sialyloligosaccharides of the respiratory epithelium in the selection of human influenza virus receptor specificity. Acta Histochem. Suppl.40:35-38.

Cited by 725 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

全球学者库

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"全球学者库"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前全球学者库共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2023 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3