The essential helicase gene RAD3 suppresses short-sequence recombination in Saccharomyces cerevisiae-Reference-Cited by-同舟云学术

The essential helicase gene RAD3 suppresses short-sequence recombination in Saccharomyces cerevisiae

Published:1995-08 Issue:8 Volume:15 Page:3998-4008
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Bailis A M¹,Maines S¹,Negritto M T¹

Affiliation:

1. Department of Molecular Genetics, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA.

Abstract

We have isolated an allele of the essential DNA repair and transcription gene RAD3 that relaxes the restriction against recombination between short DNA sequences in Saccharomyces cerevisiae. Double-strand break repair and gene replacement events requiring recombination between short identical or mismatched sequences were stimulated in the rad3-G595R mutant cells. We also observed an increase in the physical stability of double-strand breaks in the rad3-G595R mutant cells. These results suggest that the RAD3 gene suppresses recombination involving short homologous sequences by promoting the degradation of the ends of broken DNA molecules.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.15.8.3998

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4. Bailis A. M. Unpublished observations.

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