Author:
Li Cong-Ran,Zhai Qian-Qian,Wang Xiu-Kun,Hu Xin-Xin,Li Guo-Qing,Zhang Wei-Xin,Pang Jing,Lu Xi,Yuan Hong,Gordeev Mikhail Fedorovich,Chen Le-Tian,Yang Xin-Yi,You Xue-Fu
Abstract
ABSTRACTMRX-I is a potent oxazolidinone antibiotic against Gram-positive pathogens, including methicillin-resistantStaphylococcus aureus(MRSA), penicillin-resistantStreptococcus pneumoniae(PRSP), penicillin-intermediateS. pneumoniae(PISP), and vancomycin-resistant enterococci (VRE). In this study, thein vivoefficacy of orally administered MRX-I was evaluated using linezolid as a comparator. MRX-I showed the same or better efficacy than linezolid in both systemic and local infection models against the tested strains.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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