PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy-Reference-Cited by-同舟云学术

PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Jiao Yajuan¹,Kong Ning¹²,Wang Hua¹,Sun Dage¹,Dong Sujie¹,Chen Xiaoyong¹,Zheng Hao¹²,Tong Wu¹²,Yu Hai¹²,Yu Lingxue¹²,Huang Yaowei³^ORCID,Wang Huan¹,Sui Baokun⁴,Zhao Ling⁴^ORCID,Liao Ying¹,Zhang Wen⁵,Tong Guangzhi¹²,Shan Tongling¹²^ORCID

Affiliation:

1. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, People’s Republic of China

2. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou University, Yangzhou, People’s Republic of China

3. College of Animal Sciences, Zhejiang University, Hangzhou, People’s Republic of China

4. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People’s Republic of China

5. School of Medicine, Jiangsu University, Zhenjiang, People’s Republic of China

Abstract

Emerging coronaviruses (CoVs) can cause severe diseases in humans and animals, but none of the currently available drugs or vaccines can effectively control these diseases. During viral infection, the host will activate the interferon (IFN) signaling pathways and host restriction factors in maintaining the innate antiviral responses and suppressing viral replication.

Funder

The National Key Research and Development Programs of China

The National Natural Science Foundation of China

The National Natural Science Foundation of Shanghai

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00908-21

Reference67 articles.

1. Coronavirus Pathogenesis