Host T Cell Dedifferentiation Effects Drive HIV-1 Latency Stability-Reference-Cited by-同舟云学术

Host T Cell Dedifferentiation Effects Drive HIV-1 Latency Stability

Published:2022-03-09 Issue:5 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Dalecki Alexander G.¹,Greer Braxton D.¹,Duverger Alexandra¹,Strange Elan L.¹,Carlin Eric¹,Wagner Frederic¹,Shi Bi²,Lowman Kelsey E.¹,Perez Mildred¹,Tidwell Christopher¹,Kaczmarek Michaels Katarzyna³,Giattina Sophia¹,Bossmann Stefan H.⁴,Henderson Andrew J.³,Hu Hui²,Kutsch Olaf¹^ORCID

Affiliation:

1. Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA

2. Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA

3. Department of Medicine and Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA

4. The University of Kansas Medical Center, Department of Cancer Biology, Kansas City, Kansas, USA

Abstract

HIV-1 persists in a latent reservoir in memory CD4 T cells for the lifetime of a patient. Understanding the biomolecular mechanisms used by the host cells to suppress viral expression will provide essential insights required to develop curative therapeutic interventions.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01974-21

Reference234 articles.

1. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

2. Gastrointestinal Tract and the Mucosal Macrophage Reservoir in HIV Infection

3. HIV Maintains an Evolving and Dispersed Population in Multiple Tissues during Suppressive Combined Antiretroviral Therapy in Individuals with Cancer

4. HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads

5. HIV-1 target cells in the CNS

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chronic active Epstein-Barr virus disease originates from infected hematopoietic stem cells;Blood;2024-01-04

2. Glucose Metabolism and Human Immunodeficiency Virus Type 1 Infection;Infectious Diseases & Immunity;2022-09-22