Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial Treatment-Reference-Cited by-同舟云学术

Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial Treatment

Published:2021-06-17 Issue:7 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pernaute-Lau Leyre¹²,Adegnika Ayola Akim³⁴,Zhou Yitian³,Zinsou Jeannot F.⁴,Gil Jose Pedro²⁵,Krishna Sanjeev³⁴⁶,Kremsner Peter G.³⁴,Lauschke Volker M.⁷^ORCID,Velavan Thirumalaisamy P.³⁸

Affiliation:

1. BioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Lisbon, Portugal

2. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden

3. Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany

4. Centre de Recherches Medicales de Lambarene, Lambarene, Gabon

5. Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, UNL, Lisbon, Portugal

6. Institute for Infection Immunity, St George’s University of London, London, United Kingdom

7. Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden

8. Vietnamese-German Center for Medical Research, VG-CARE, Hanoi, Vietnam

Abstract

Malaria remains one of the deadliest diseases in Africa, particularly for children. While successful in reducing morbidity and mortality, antimalarial treatments are also a major cause of adverse drug reactions (ADRs).

Funder

Deutsche Forschungsgemeinschaft

European Commission

Innovative Medicines Initiative

UNL | Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa

Vetenskapsrådet

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00275-21