Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis-Reference-Cited by-全球学者库

Combination of Amphotericin B and Terbinafine against Melanized Fungi Associated with Chromoblastomycosis

Published:2018-06 Issue:6 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Deng S.¹,Lei W.²,de Hoog G. S.²³⁴⁵,Yang L.³,Vitale R. G.⁶,Rafati H.⁷,Seyedmousavi M.⁷,Tolooe A.⁷,van der Lee H.⁵,Liao W.²,Verweij P. E.⁵,Seyedmousavi S.⁵⁷⁸^ORCID

Affiliation:

1. Department of Medical Microbiology, People's Hospital of Suzhou National New & Hi-Tech Industrial Development Zone, Jiangsu, China

2. Shanghai Institute of Medical Mycology, Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China

3. Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands

4. Basic Pathology Department, Federal University of Paraná State, Curitiba, Paraná, Brazil

5. Department of Medical Microbiology, Radboud University Medical Center, and Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands

6. CONICET and Ramos Mejia Hospital, Parasitology Unit, Mycology Section, Buenos Aires, Argentina

7. Center of Excellence for Infection Biology and Antimicrobial Pharmacology, Tehran, Iran

8. Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Abstract

ABSTRACT Our in vitro studies showed that a combination of amphotericin B and terbinafine had synergistic effects against the majority of melanized fungi associated with chromoblastomycosis (CBM) and similar infections, including those with Cladophialophora carrionii , Cladophialophora arxii , Exophiala dermatitidis , Exophiala spinifera , Fonsecaea monophora , Fonsecaea nubica , Fonsecaea pedrosoi , and Phialophora verrucosa. This drug combination could provide an option for the treatment of severe or unresponsive cases of CBM, particularly in cases due to species of Fonsecaea and Cladophialophora .

Funder

973 Program of China

Center of Excellence for Infection Biology and Antimicrobial Pharmacology, Tehran, Iran

CBS-KNAW, Netherlands

RadboudUMC, Netherlands

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00270-18