Pathogenicity and Structural Basis of Zika Variants with Glycan Loop Deletions in the Envelope Protein-Reference-Cited by-全球学者库

Pathogenicity and Structural Basis of Zika Variants with Glycan Loop Deletions in the Envelope Protein

Published:2022-12-14 Issue:23 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Cheng Meng-Li¹²,Yang Yun-Xiang³,Liu Zhong-Yu¹⁴,Wen Dan⁵,Yang Pan³,Huang Xing-Yao¹,Dong Hao-Long¹,Xu Yan-Peng¹,Li Xiao-Feng¹,Deng Yong-Qiang¹,Ye Qing¹,Zhu Ling³,Li Juan⁶,Davidson Andrew D.⁷,Zheng Ai-Hua⁵^ORCID,Shi Wei-Feng⁶^ORCID,Zhao Hui¹,Wang Xiang-Xi³,Qin Cheng-Feng¹²^ORCID

Affiliation:

1. Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China

2. School of Basic Medicine, Anhui Medical University, Hefei, China

3. CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

4. School of Medicine (Shenzhen), Sun Yat-sen University, Guangzhou, China

5. State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

6. Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University/Shandong Academy of Medical Sciences, Taian, China

7. Faculty of Life Sciences, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

Abstract

Zika virus (ZIKV) has been identified as a cause of microcephaly and acquired evolutionary mutations since its discovery. Previously deletions in the E glycan loop were recorded in African ZIKV strains, which have re-emerged in the contemporary Asian lineages recently.

Funder

NSFC | National Science Fund for Distinguished Young Scholars

Foundation for Innovative Research Groups of the National Natural Science Foundation of China

Innovation fund for medical science from Chinese of Medical Scienceacademy

MOST | 高端外国专家引进计划 | National Ten Thousand Talent Program

Taishan Scholar Foundation of Shandong Province

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00879-22

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