Antibacterial Properties of MagnesiumIn Vitroand in anIn VivoModel of Implant-Associated Methicillin-Resistant Staphylococcus aureus Infection-Reference-Cited by-同舟云学术

Antibacterial Properties of MagnesiumIn Vitroand in anIn VivoModel of Implant-Associated Methicillin-Resistant Staphylococcus aureus Infection

Published:2014-10-06 Issue:12 Volume:58 Page:7586-7591
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Li Yang,Liu Guangwang,Zhai Zanjing,Liu Lina,Li Haowei,Yang Ke,Tan Lili,Wan Peng,Liu Xuqiang,Ouyang Zhengxiao,Yu Zhifeng,Tang Tingting,Zhu Zhenan,Qu Xinhua,Dai Kerong

Abstract

ABSTRACTPeriprosthetic infection remains a challenging clinical complication. We investigated the antibacterial properties of pure (99.9%) magnesium (Mg)in vitroand in anin vivorat model of implant-related infection. Mg was highly effective against methicillin-resistantStaphylococcus aureus-induced osteomyelitis and improved new peri-implant bone formation. BacterialicaAandagrRNAIII transcription levels were also assessed to characterize the mechanism underlying the antibacterial properties of the Mg implant.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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