Tremorgenic Toxin from Penicillium verruculosum-Reference-Cited by-同舟云学术

Tremorgenic Toxin from Penicillium verruculosum

Published:1972-08 Issue:2 Volume:24 Page:248-250
ISSN:0003-6919
Container-title:Applied Microbiology
language:en
Short-container-title:Appl Microbiol

Author:

Cole R. J.¹²,Kirksey J. W.¹²,Moore J. H.¹²,Blankenship B. R.¹²,Diener U. L.¹²,Davis N. D.¹²

Affiliation:

1. National Peanut Research Laboratory, U.S. Department of Agriculture, Dawson, Georgia 31742

2. Department of Botany and Microbiology, Auburn University Agricultural Experiment Station, Auburn, Alabama 36830

Abstract

A new mycotoxin that produces severe tremors and acute toxicity when administered orally or intraperitoneally (ip) to mice and 1-day-old cockerels was obtained from a strain of Penicillium verruculosum Peyronel isolated from peanuts. The ip 50% lethal dose (LD 50 ) of this tremorgen was 2.4 mg/kg in mice and 15.2 mg/kg in chickens. Orally administered LD 50 values for the toxin were 126.7 mg/kg in mice and 365.5 mg/kg in chickens. The trivial name “verruculogen” is proposed for this tremorgenic mycotoxin. Physical and chemical characteristics of the mycotoxin are described.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://journals.asm.org/doi/pdf/10.1128/am.24.2.248-250.1972

Reference6 articles.

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