Laccase Expression in Murine Pulmonary Cryptococcus neoformans Infection

Author:

Garcia-Rivera Javier1,Tucker Stephanie C.1,Feldmesser Marta12,Williamson Peter R.3,Casadevall Arturo12

Affiliation:

1. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York

2. Division of Infectious Disease, Albert Einstein College of Medicine, Bronx, New York

3. Division of Infectious Disease, University of Illinois at Chicago College of Medicine, Chicago, Illinois

Abstract

ABSTRACT Cryptococcus neoformans laccase expression during murine infection was investigated in lung tissue by immunohistochemistry and immunogold electron microscopy. Laccase was detected in the fungal cell cytoplasm, cell wall, and capsule in vivo. The amount of laccase found in different sites varied as a function of the time of infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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