Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma-Reference-Cited by-同舟云学术

Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Yue Kaile¹²,Sheng Dashuang¹²,Xue Xinxin¹²,Zhao Lanlan¹²,Zhao Guoping¹²³⁴,Jin Chuandi¹²,Zhang Lei¹²³^ORCID

Affiliation:

1. Microbiome-X, National Institute of Health Data Science of China, Shandong University, Jinan, China

2. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China

3. State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China

4. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

Abstract

The burgeoning field of oncobiome research declared that members of the intratumoral microbiome besides Helicobacter pylori existed in tumor tissues and participated in the occurrence and development of gastric cancer, and the methylation of host DNA may be a potential target of microbes and their metabolites. Current research focuses mostly on species composition, but the functional genes of the members of the microbiota are also key to their interaction with the host.

Funder

MOST | National Natural Science Foundation of China

Taishan Industry Leading Talents

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00904-23

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