Bacterial Outer Membrane Polysaccharide Export (OPX) Proteins Occupy Three Structural Classes with Selective β-Barrel Porin Requirements for Polymer Secretion-Reference-Cited by-同舟云学术

Bacterial Outer Membrane Polysaccharide Export (OPX) Proteins Occupy Three Structural Classes with Selective β-Barrel Porin Requirements for Polymer Secretion

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Saïdi Fares¹²^ORCID,Mahanta Utkarsha³^ORCID,Panda Adyasha³^ORCID,Kezzo Ahmad A.¹²^ORCID,Jolivet Nicolas Y.¹²^ORCID,Bitazar Razieh¹²,John Gavin⁴,Martinez Matthew⁵,Mellouk Abdelkader¹²,Calmettes Charles¹²^ORCID,Chang Yi-Wei⁵^ORCID,Sharma Gaurav³^ORCID,Islam Salim T.¹²^ORCID

Affiliation:

1. Institut National de la Recherche Scientifique (INRS), Centre Armand-Frappier Santé Biotechnologie, Université du Québec, Institut Pasteur International Network, Laval, Quebec, Canada

2. PROTEO, the Quebec Network for Research on Protein Function, Engineering, and Applications, Université Laval, Québec, Quebec, Canada

3. Institute of Bioinformatics and Applied Biotechnology (IBAB), Bengaluru, Karnataka, India

4. Department of Pediatrics, Division of Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

5. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

Diverse bacteria assemble and secrete polysaccharides that alter their physiologies through modulation of motility, biofilm formation, and host immune system evasion. Most such pathways require outer membrane (OM) polysaccharide export (OPX) proteins for sugar-polymer transport to the cell surface.

Funder

PROTEO

Department of Science and Technology (DST), India

Armand-Frappier Foundation

David and Lucile Packard Foundation

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01290-22